Luis Girón Negrón's primary areas of research are the literatures of the Iberian peninsula in the Middle Ages and early modern period. He is particularly interested in the interplay of Spanish, Arabic and Hebrew literatures (as well as Latin, Galician-Portuguese and Catalan), and the intersections of religion and literature in premodern European cultures. Related interests include the theory and practice of translation, bilingual aesthetics, intellectual history, comparative mysticism and humanist philology.
Currently, he is working on a book-length monograph entitled "The Hawk Is Not Worth Less": Jews and Judaism in Medieval Castilian Literature. He is also preparing a study and anthology of Hispano-Latin narratives on the translation of saints and the theft of relics, and a critical edition of the 14th century Coplas de Yoçef in Judeo-Spanish aljamiado.
Prof. Girón Negrón has served on the Committee on the Study of Religion since 2007.